Controlling skin damage is one of the ways to stimulate skin remodeling, used in cosmetic procedures and aesthetic medicine treatments. Interruption of the skin’s continuity favors the emergence of local inflammation and increased synthesis of collagen fibers. One of the most-chosen treatments of this type is microneedle mesotherapy. It is an effective therapy inducing the synthesis of new collagen fibers, which leads to skin rejuvenation and reduction of certain skin defects. Most often, microneedle mesotherapy is performed on the face, neck and cleavage, as well as the scalp; other possible locations are areas of the body that require skin regeneration.